tim3 (R&D Systems)
R&D Systems is a verified supplier 
R&D Systems manufactures this product 
94
Structured Review
R&D Systems
tim3
Tim3, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+tim3/Human+TIM-3+Antibody/bio_rxiv__64898__2026__03__27__714741-48-9-11
Average 94 stars, based on 7 article reviews
Tim3, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+tim3/Human+TIM-3+Antibody/bio_rxiv__64898__2026__03__27__714741-48-9-11
Average 94 stars, based on 7 article reviews
tim3 - by Bioz Stars,
2026-11
94/100 stars
Images
1) Product Images from "Single-Cell Profiling Reveals Developmental Trajectories and identifies SYK and TIM3 as Targets in some T Cell Lymphomas"
Article Title: Single-Cell Profiling Reveals Developmental Trajectories and identifies SYK and TIM3 as Targets in some T Cell Lymphomas
Journal: bioRxiv
doi: 10.64898/2026.03.27.714741
Figure Legend Snippet: (A) A UMAP showing the integration of tumour and benign cells of the TME, and healthy lymph node data from two public studies (PMID35027729, PMID39566559). Cells are coloured according to the data source, and scANVI-predicted cell types are shown in (B), (C) and (D). Images of an ALK+ ALCL case colored by Cell2location-predicted cell type abundances in each Visium spot. (C) Predictions for the locations of malignant cells, TIM3+ T cells (T_TIM3+) and cytotoxic T cells (T_CD8+_cytotoxic), (D) Predictions for the locations of dark zone B cells (B_GC_DZ), light zone B cells (B_GC_LZ) and follicular dendritic cells (FDC). (E) A dotplot showing non-negative matrix factorisation (NMF) factors, where each factor is a group of co-localized cell types. In the dotplot, the size and color density represent the loading of each cell type in each factor. (F) Staining of TIM3 and CD30 expression on two representative ALK+ ALCL cases (G) Summary of the % TIM3+ infiltrating T lymphocytes in each of the 9 ALK+ ALCL cases analysed.
Techniques Used: Staining, Expressing
Related Articles
Bioprocessing:Article Title: Bispecific antibodies specific for PD1 and TIM3 Article Snippet: .. Examples of the anti-TIM3 monoclonal antibodies include other:Article Title: Desmoplasia Is Associated with Decreased Cytotoxic and Helper T Cells and Increased T-Cell Exhaustion in Cutaneous Squamous Cell Carcinoma. Article Snippet: TO THE EDITOR Although the vast majority of cutaneous squamous cell carcinoma (CSCC) are easily curedwith surgical excision, 1e3% of cases result in death, making deaths from CSCC similar in number to those from melanoma (Karia et al, 2014).. Despite this, mechanisms governing aggressive behavior/metastasis remain largely undefined (Stang et al, 2019).. Food and Drug Administrationeapproved immunotherapies exist for unresectable CSCCs; however, they have an approximate response rate of 50% with few complete responses and subsequently a high riskof disease-specificdeath (Migden et al, 2018). Article Title: Dexamethasone potentiates chimeric antigen receptor Tcell persistence and function by enhancing IL-7R expression Article Snippet: After 7 days, CD3/CD28 Dynabeads beads were removed using a DynaMag-5 Magnet (Invitrogen, 12303D) and 7 105 cells/mL were plated in RPMI 1640/10% FBS, 50 U/mL rhIL-2, and 0.5 ng/mL rhIL-15 to rest for 48 h. CAR T cells were cultured for 16–24 days before being used in in vitro experiments or being frozen in CryoStor (Biolife Solutions, 205102) for mouse experiments. Article Title: Human effector CD8 + T cells with an activated and exhausted-like phenotype control tumour growth in vivo in a humanized tumour model. Article Snippet: Findings We found human T cell subsets described in human cancer, including progenitor exhausted (Tpex), terminally exhausted (Tex-term) and tissue-resident (TRM) cells in tumour-bearing humanized mice with accumulation of Tex-term and TRM in the tumour.. In addition, we identified tumour-reactive CD8 + T cells through expression of CD137.. This subpopulation of de novo arising human CD137 CD8 T cells displayed a highly proliferative, fully activated effector and exhausted-like phenotype with enhanced expression of activation and exhaustion markers like PD-1, CD39, CD160, TIM-3, TIGIT and TOX, the senescence marker CD57 (B3GAT1) and cytolytic effector molecules such as PRF1, GZMH and NKG7. Staining:Article Title: Single-Cell Profiling Reveals Developmental Trajectories and identifies SYK and TIM3 as Targets in some T Cell Lymphomas Article Snippet: Immunohistochemistry was performed on formalin-fixed paraffin-embedded (FFPE) tissue from 9 independent ALK+ ALCL patients using standard protocols on a Discovery-XT staining device (Ventana). .. Following heat-mediated antigen retrieval, consecutive sections were stained for Article Title: Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire Article Snippet: Blood was taken from uninfected mice and infected humanized mice 3 weeks post-infection and stained using flow cytometry with PE-Cy7 conjugated anti-PD1 antibody (BIOLEGEND), PerCpCy5.5 conjugated Lag3 antibody (BIOLEGEND), and PE conjugated Tim3 antibody (R&D Systems). .. Blood was taken from uninfected mice and infected humanized mice 3 weeks post-infection and stained using flow cytometry with PE-Cy7 conjugated anti-PD1 antibody (BIOLEGEND), PerCpCy5.5 conjugated Lag3 antibody (BIOLEGEND), and Infection:Article Title: Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire Article Snippet: Blood was taken from uninfected mice and infected humanized mice 3 weeks post-infection and stained using flow cytometry with PE-Cy7 conjugated anti-PD1 antibody (BIOLEGEND), PerCpCy5.5 conjugated Lag3 antibody (BIOLEGEND), and PE conjugated Tim3 antibody (R&D Systems). .. Blood was taken from uninfected mice and infected humanized mice 3 weeks post-infection and stained using flow cytometry with PE-Cy7 conjugated anti-PD1 antibody (BIOLEGEND), PerCpCy5.5 conjugated Lag3 antibody (BIOLEGEND), and Flow Cytometry:Article Title: Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire Article Snippet: Blood was taken from uninfected mice and infected humanized mice 3 weeks post-infection and stained using flow cytometry with PE-Cy7 conjugated anti-PD1 antibody (BIOLEGEND), PerCpCy5.5 conjugated Lag3 antibody (BIOLEGEND), and PE conjugated Tim3 antibody (R&D Systems). .. Blood was taken from uninfected mice and infected humanized mice 3 weeks post-infection and stained using flow cytometry with PE-Cy7 conjugated anti-PD1 antibody (BIOLEGEND), PerCpCy5.5 conjugated Lag3 antibody (BIOLEGEND), and |